| Mailed Communications | Date Distributed |
| NEWSLETTER Columbia 2018 | December 2018 |
| NEWSLETTER Columbia 2017 | December 2017 |
| NEWSLETTER Columbia 2015 | August 2015 |
Stephanie Cosentino, PhD
Associate Professor of Neuropsychology
Cognitive Neuroscience Division
Department of Neurology, Taub Institute and Sergievsky Center
Columbia University Medical Center
630 West 168th Street
P&S Mailbox 16
NY NY 10032
sc2460@cumc.columbia.edu
(212) 342-0289 phone
(212) 342-1838 fax
Dr. Cosentino’s research has examined the cognitive, behavioral, and metacognitive profiles of various neurodegenerative diseases, particularly Alzheimer’s disease and Frontotemporal dementia (FTD). The overarching goals of her current work are to characterize the factors that explain metacognitive variability along the spectrum of healthy to pathological aging, and to identify the practical consequences of metacognitive impairment for everyday decision making and quality of life. A related goal is the examination, refinement and development of tools to assess subjective cognition and metacognition in older adults in order to clarify the prognostic relevance of cognitive complaints in healthy older adults and the nature of disordered metacognition in neurodegenerative conditions.
Joseph H Lee, DrPH, Associate Professor
Sergievsky Center/Taub Institute & Epidemiology, Columbia University
630 W 168th Street, NY, NY 10032
(212) 305-6022 phone
(212) 342-5144
JHL2@columbia.edu
or
JHL2@cumc.columbia.edu
Skype/Google+: Joseph.Lee.2005
Joseph H. Lee, DrPH, studies the biology of aging traits in several unique populations in different parts of the world. To this end, he has four areas of research. First, Dr. Lee and colleagues are studying large Caribbean Hispanic families with multiple affected relatives to identify genes that contribute to Alzheimer disease (AD). Currently, he is focusing on families that carry a founder mutation in the PSEN1 gene to identify protective genetic factors. To identify genetic factors that alter AD risk, he applies genome-wide linkage and association, whole genome/exome sequencing, RNA-sequencing, transcriptomics, and other functional genetic approaches. Second, Dr. Lee and colleagues are examining adults with Down syndrome (DS) to better understand the aging brain. Adults with DS age faster than the general population, and they start developing AD neuropathologies in their 40s. He and his colleagues apply multi-omic approaches (including genomic, proteomic, and metabolomics and phenomics) to examine the disease processes. Third, he and colleagues are conducting a multi-site longitudinal study to determine why some individuals live to exceptionally old age and remain healthy. This study examines genome-phenome relations in several hundred longevous families. Fourth, he and colleagues are studying migrant populations to interrogate gene-environment interaction. By examining individuals who share the same genetic background but are exposed to disparate environments, they will be able to explore the influence of environment on genetic factors. In addition, he and his collaborators are investigating a cohort of inbred American-Indians in Venezuela to identify and characterize genetic and environmental factors that contribute to the relations between dementia and cardio-metabolic risk factors.
Websites:
Columbia University
New York, New York
http://www.cumc.columbia.edu/dept/sergievsky/
http://www.cumc.columbia.edu/dept/taub/
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